Learn about Pfizer’s clinical research into a potential targeted therapy for colorectal cancer.

Colorectal cancer, also called colon cancer, is the second leading cause of cancer death in the United States. Pfizer is currently conducting a clinical trial with a focus on colorectal cancer that:

  • is advanced or metastatic (spread to other parts of the body);
  • has a certain type of abnormal gene called “BRAF”

About 10 to 15 percent of people with colorectal cancer have the abnormal BRAF gene, which causes cancer cells to multiply out of control. Identifying whether a person with colorectal cancer has the BRAF gene is an important way to identify an appropriate treatment.

In addition to conducting a clinical trial focused on BRAF-positive colorectal cancer, we are also evaluating other approaches and potential treatments.

If you or a loved one are considering taking part in a colorectal cancer clinical trial, find more information below. With your participation, clinical research might help to identify better treatment options for people with colorectal cancer.

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      9 trials found

      All(9)
      Recruiting(8)
      Not yet recruiting(1)
      Recruiting
      NCT04557449
      Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors

      Liposarcoma, Prostate Cancer, Breast Neoplasms, Adenocarcinoma of Lung

      Male or Female
      18+ years
      92study location(s)
      Recruiting
      NCT05538130
      A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors

      Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal Cancer

      Male or Female
      16+ years
      74study location(s)
      Recruiting
      NCT05253651
      A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

      Colorectal Neoplasms

      Male or Female
      18+ years
      227study location(s)
      Recruiting
      NCT03485209
      Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors

      Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Exocrine Pancreatic Cancer, Carcinoma, Squamous Cell of Head and Neck

      Male or Female
      18+ years
      52study location(s)
      Recruiting
      NCT06580938
      A Study to Learn About PF-07921585 Alone or With Other Anti-cancer Medicines in People With Cancer

      Non Small Cell Lung Cancer, Bladder Cancer, Renal Cell Carcinoma, Melanoma, Head and Neck Cancer, Colorectal Cancer

      Male or Female
      18+ years
      8study location(s)
      Recruiting
      NCT06466187
      A Study of SGN-MesoC2 in Advanced Solid Tumors

      Carcinoma, Non-Small-Cell Lung, Ovarian Neoplasms, Pancreatic Adenocarcinoma, Colorectal Neoplasms, Mesothelioma, Other Solid Tumors

      Male or Female
      18+ years
      3study location(s)
      Recruiting
      NCT06549816
      A Study of SGN-B6A in Chinese Participants With Advanced Solid Tumors

      Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma, Esophageal Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma

      Male or Female
      18+ years
      3study location(s)
      Recruiting
      NCT05571839
      A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors

      Cutaneous Melanoma, Non-small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Neoplasms, Mesothelioma

      Male or Female
      18+ years
      20study location(s)
      May 16, 2025 - Planned start date (Not yet recruiting)
      NCT04889495
      A Post-marketing Surveillance to Assess the Safety and Effectiveness of Zirabev in Domestic Patients With Various Cancer

      Non-small Cell Lung Cancer, Metastatic Colorectal Cancer, Metastatic Breast Cancer, Metastatic Kidney Cancer, Cervical Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer

      Male or Female
      19+ years
      1study location(s)

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      All(9)
      Recruiting(8)
      Not yet recruiting(1)

      Contact us

      For more information about participation in a Pfizer clinical trial, please email or call the Pfizer Clinical Trial Contact Center at 1-800-887-7002.


      About colorectal cancer

      Colorectal cancer, also known as colon cancer, occurs when tumors form in the lining of the large intestine. The risk of developing colorectal cancer increases after age 50. Colorectal cancer is common in both men and women.

      In addition to age, risk factors include having a family history of colorectal cancer, having ulcerative colitis or Crohn’s disease, eating a diet high in fat, or smoking.

      Colorectal cancer symptoms include diarrhea or constipation, a feeling that the bowel does not empty completely, blood in the stool, or frequent gas pains or cramps. There may be no symptoms initially, which is why it is important to have colorectal cancer screening tests.